Cellular and Molecular Immunology - International Edition 11e

• Highlights the implications of immunologic science for the management of human disease, emphasizing clinical relevance throughout
• Employs a highly accessible writing style that makes difficult concepts easier to understand, and provides clear implications of immunologic science to the management of human disease and clinical practice
• Features updates from cover to cover, including new information on COVID-19, genetics and pathogenesis of allergic diseases, newly recognized primary immune regulatory disorders, interactions between the immune system and brain and their role in CNS disorders, and CRISPR/Cas9 based gene editing
• Provides a highly visual, full-color description of the key immunologic and molecular processes with a fully updated, comprehensive, and consistent art program, including many new and extensively revised illustrations
• Helps readers grasp the details of experimental observations that form the basis for the science of immunology at the molecular, cellular, and whole-organism levels and draw the appropriate conclusions
• Includes summary boxes that assist with rapid review and mastery of key material

By Abul K. Abbas, MBBS, Emeritus Professor, Department of Pathology, University of California San Francisco, USA; Andrew H. Lichtman, MD, PhD, Professor of Pathology, Brigham and Women's Hospital, Harvard Medical School, USA; Shiv Pillai, MD, PhD, Professor of Medicine and Health Sciences and Technology, Harvard Medical School, Ragon Institute of MGH, MIT and Harvard, USA and Sarah Henrickson, MD, PhD, Assistant Professor, Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia Department of Pediatrics, Perelman School of Medicine Department of Microbiology, Perelman School of Medicine, USA

 

Table of Contents

 

1. Overview of the Immune System
2. Cells and Tissues of the Immune System
3. Leukocyte Circulation and Migration Into Tissues
4. Innate Immunity
5. Antibodies and Antigens
6. Antigen Presentation to T Lymphocytes and the Role of Major Histocompatibility Complex Molecules
7. Immune Receptors and Signal Transduction
8. Lymphocyte Development and Antigen Receptor Gene Rearrangement
9. Activation and Regulation of T Lymphocytes
10. Differentiation and Functions of CD4 + Effector T Cells
11. Differentiation and Functions of CD8 + Effector T Cells
12. B-Cell Activation and Antibody Production
13. Effector Mechanisms of Humoral Immunity
14. Specialized Immunity at Epithelial Barriers and in Immune-Privileged Tissues
15. Immunologic Tolerance and Autoimmunity
16. Immunity to Microbes
17. Transplantation Immunology
18. Tumor Immunology
19. Hypersensitivity Disorders
20. Allergy
21. Congenital and Acquired Immunodeficiencies